Abstract
The interval treatment of chronic relapsing peptic ulcer of the stomach and duodenum with Antispasmodic Compound 8–88 appears to extend the duration of the remission period (over 1 year) in a large percentage of cases. This therapeutic effect does not result from a decrease of the secretory activity of the gastric glands, since no significant changes in the output of gastric juice and all the glandular secretory products of the stomach (acid, pepsin, mucoprotein) were observed following this treatment. Anticholinergic drugs and antacids are more effective than Compound 8–88 in the treatment of peptic ulcer during the period of relapse. The tolerance to the treatment with Compound 8–88 in a daily dose of 50 mg. 4 times a day or 100 mg. 3 times a day was good and side effects were slight.
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