Abstract
The discovery of novel compounds with pharmaceutical application in cyanobacterias suggests that Blennothrix ganeshii and Microcoleous lacustrisMexican species can be candidates for the bioprocess of target compounds. The antispasmodic effect of hexane, chloroform, methanol and water extracts of B. ganeshii and M. lacustris were studied in vitro in guinea pig ileum against three spasmogens; acetylcholine, histamine and barium chloride. In all cases, the hexane extract produces a significant antispasmodic effect on the contractions of the rat ileum induced by acetylcholine, histamine and barium chloride. The inhibitory concentration for each was determined. These results show that hexane extract of B. ganeshii, and M. lacustris possesses both anticholinergic and antihistaminic properties. Key words: Antispasmodic activity, Blennothrix ganeshii, cyanobacteria,Microcoleous lacustris.
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