Abstract
Pimaradienoic acid (PA, 1) is a pimarane-type diterpene which is associated with a wide spectrum of biological activities, including its great ability to inhibit rat aorta contraction [1]. In the present work, the fungal transformation of PA (0.1g/L) was performed using culture of Aspergillus niger (1.5×107 spores/mL) during 9 days of incubation. After this period, the culture was filtered and the aqueous layer was extracted with ethyl acetate to furnish the extract codified as AtPA. Chemical and NMR studies of AtPA allowed us to isolate and to identify four PA derivatives (2–5). The chemical structures of 2, 4 and 5 are described for the first time in the scientific literature.
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