Antiserotonin and antihistaminic properties of derivatives of 2-methyl-3-ethoxycarbonyl-4-dialkylaminomethyl-5-hydroxyindole

Abstract

An investigation has been made of derivatives of the 4-dialkylaminoalkyl-5-hydroxyindoles obtained from the corresponding 5-hydroxyindoles by the action of bis(dimethylamino) methane and bis(diethylamino) methane. It has been found that the derivatives of 4-dialkylaminoalkyl-5-hydroxyindoles possess ananti-serotonin action. In experiments on animals, compounds IV–VI and VIII with a dimethylaminomethyl substituent in position 4 and o-tolyl, p-anisyl, p-tolyl, and m-chlorophenyl substituents on the nitrogen of the indole ring, respectively, proved to be the most active. The compounds studied did not exhibit antihistaminic activity.