Abstract
Messenger RNA decay is an important mechanism forcontrolling gene expression in all organisms. The rate ofthe mRNA degradation directly affects the steady stateconcentration of mRNAs and therefore influences the pro-tein synthesis. It is assumed that RNase E is the initialpoint for general mRNA decay in
Highlights
Messenger RNA decay is an important mechanism for controlling gene expression in all organisms
As RNase E is essential for cell viability and knockout mutants can be not cultured, we investigated the possibility for down-regulation of the level of RNase E by antisense RNAs
When the cells passed into the stationary phase the level of expressed antisense RNAs decreased markedly
Summary
Messenger RNA decay is an important mechanism for controlling gene expression in all organisms. Antisense RNA based control of detrimental factors for recombinant gene expression in Escherichia coli – down-regulation of RNase E The 4th Recombinant Protein Production Meeting: a comparative view on host physiology The organisers would like to thank Novozymes Delta Ltd who generously supported the meeting. Meeting abstracts – A single PDF containing all abstracts in this supplement is available here http://www.biomedcentral.com/content/pdf/1475-2859-5-S1-info.pdf
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