Abstract
Breast cancer has become the most common form of cancer worldwide. Chemotherapy failure, primarily due to drug resistance, necessitates the development of new therapeutic strategies. In this study, ultrathin Ti3C2 nanosheets are utilized as photothermal agents and nanocarriers. We developed a multifunctional Ti3C2-based nanoplatform (214.7 nm) through layer-by-layer absorption of HSP90 antisense oligonucleotide (ASO) and doxorubicin (DOX), with surface modification using hyaluronic acid (HA). In a simulated acidic tumor microenvironment in vitro, 90 % of the drug was released within 36 hours. Additionally, Under 808 nm irradiation (2.0 W/cm²), MCF-7/ADM cell viability assays revealed the following results: HA-Ti3C2 (57 %), HA-Ti3C2@ASO (HT@A) (41 %), and HA-Ti3C2@ASO/DOX (HT@AD) (26 %), which shown the synergistic inhibitory effects of this multifunctional nanoplatform. Herein, this nanosystem exhibits enhanced biocompatibility, superior photothermal performance, and stimuli-responsive drug release behavior, making it a promising candidate for effective inhibition of cancer cell proliferation and migration.
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