Abstract
Background Cytotoxic T-lymphocytes (CTLs) are essential for suppression of viral replication and, in particular, they have a pivotal role in control of progression of HIV infection. It has been demonstrated that HIV-specific CTL responses are defective in HIV-infected patients undergoing highly active antiretroviral therapy (HAART). In this study we investigated the effects of antiretroviral compounds on the granule-dependent mechanisms of lysis in peripheral blood mononuclear cells (PBMCs).
Highlights
Cytotoxic T-lymphocytes (CTLs) are essential for suppression of viral replication and, in particular, they have a pivotal role in control of progression of HIV infection
It has been demonstrated that HIV-specific CTL responses are defective in HIV-infected patients undergoing highly active antiretroviral therapy (HAART)
In this study we investigated the effects of antiretroviral compounds on the granule-dependent mechanisms of lysis in peripheral blood mononuclear cells (PBMCs)
Summary
Antiretroviral compounds affect the granule-dependent mechanisms of lysis in CD8 T cells Anita Parmigiani*, Daria Trabattoni and Mario Clerici. Address: Department of Immunology, University of Milano, Milano, Italy * Corresponding author. Open Access from 2006 International Meeting of The Institute of Human Virology Baltimore, USA. 17–21 November, 2006 Published: 21 December 2006 Retrovirology 2006, 3(Suppl 1):P49 doi:10.1186/1742-4690-3-S1-P49. 2006 International Meeting of The Institute of Human Virology Meeting abstracts. A single PDF containing all abstracts in this Supplement is available here http://www.biomedcentral.com/content/pdf/1742-4690-3-S1-info.pdf
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