Abstract
Aim. Considering the high biological activity of the components of the St. John’s wort, we conducted studies to identify its radioprotective effect. Methods. Studies were conducted on adult Vistar rats with an average weight of 100-120 grams.3 hours before irradiation, the extract from St. John’s wort was intraperitoneally administered to animals at a concentration of 50 mg/kg. Irradiation was carried out once with doses of 5 and 7 Gy on the “Rhund-20000” facility with an average radiation dose rate MD = 0.3069 Gr/s. The frequency of chromosomal abnormalities was recorded on the mitotic cells of the bone marrow. Results. Acute irradiation with a dose of 5 Gy led to cell division inhibition. The number of chromosomal aberrations increased due to structural disorders (deletions, fragments, inversions) up to 6.8%.In animals that received a dose of 7 Gy after a single irradiation, the frequency of chromosomal abnormalities increased to 11.02%. The introduction of the Hypericum perforatum L. extract softened the effect of ionizing radiation, reducing the mutational effect of radiation. It not only contributed to the restoration of the cell division, but also reduced the proportion of structural disorders. Conclusions. Hypericum extract can be considered to be promising as an anti-radiation agent of plant origin.
 Keywords: rats, chromosomal abnormalities, marrow, irradiation, extract.
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