Abstract
Active mono-S-alkyl esters prepared from 1-(dithio-acetic acid)-pyridinium betaine (III) were found to be sufficiently stable for screening as radiation-protective agents, and e-withdrawing substituents in the pyridine ring gave stable betaines. Reaction of the methyl ester of III with phenacyl bromide and alkali resulted in S-alkylation to give a ketene mercaptal betaine (VIII). Both the allyl and p-nitrobenzyl esters of 1-(dithioacetic acid)-pyridinium halides were radiation-protective in mice, and betaines with substituents in the pyridine ring were radiation-protective in a bacterial test.
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