Abstract
Fever was induced in rats with a single i.p. injection of 30 μg/kg E. coli endotoxin. The effect of the alcohol leaf extract of Azadirachta indica was investigated in this model. Pretreatment of rats with the leaf extract (125–375 mg/kg) did not significantly reduce endotoxin-induced fever. The rectal temperature remained significantly high. In contrast, administration of the same doses of the extract during the early phase of fever development (during temperature rise) produced a significant fall in the rectal temperature to near normal. The maximum rise was 1.0°C which later dropped to 0.18°C, and was sustained even beyond the experimental session. The data obtained suggest the beneficial antipyretic effect of the leaf extract of Azadirachta indica in bacteria endotoxin induced fever. © 1998 John Wiley & Sons, Ltd.
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