Antipsychotic property of EGIS 11150 (S 36549) in phencyclidine-induced disruption of prepulse inhibition in rats and mice

Abstract

Event Abstract Back to Event Antipsychotic property of EGIS 11150 (S 36549) in phencyclidine-induced disruption of prepulse inhibition in rats and mice Krisztina Moricz1*, Gabor Gigler1, Hajnalka Kompagne1, Szabolcs Kertesz1, Marta Agoston1, Katalin Nagy1, Jozsef Barkoczy1, Gabor Szenasi1 and Istvan Gacsalyi1 1 EGIS Pharmaceuticals Plc., CTCN, Hungary Prepulse inhibition (PPI) is disrupted in schizophrenic patients and the degree of reflex inhibition is an operational measure of sensorimotor gating. NMDA antagonist such as phencyclidine (PCP) also disrupts PPI in animals when administrated acutely, and this effect can be prevented by antipsychotics (preferentially atypical ones). EGIS-11150 is a new atypical antipsychotic agent developed by EGIS Pharmaceutical Plc. Earlier we demonstrated that the compound possessed strong procognitive and neuroprotective effects and exerted strong antipsychotic activity in a series of animal models of the negative and positive symptoms of schizophrenia. (Gacsályi et al. 2007) The aim of the present study was to examine the effects of EGIS 11150 in phencyclidine-induced disruption of prepulse inhibition in rats and mice. In rats EGIS 11150 restored the deficit of PPI - induced by 2 mg/kg PCP - in 0.1, 0.3 and 1 mg/kg i.p. administrated at 30 min before the test. In mice the PPI was disrupted by 10 mg/kg PCP sac. (-30 min). EGIS 11150 was effective in 0.01, 0.03 and 0.1 mg/kg doses i.p. The compound decreased the startle magnitudes in all studied doses in rats and the largest dose in mice. If we administrated EGIS 11150 alone, although it reduced the startle amplitudes in largest doses, it did not show effect on PPI. This result suggests that the startle amplitude reducing effect of the compound is separate from the PPI deficit-restoring efficacy.In the present studies EGIS 11150 processed a remarkable properties to restore the PPI deficit induced by PCP, which confirmed that it may be a potential therapeutic agent in the treatment of schizophrenia. Conference: 41st European Brain and Behaviour Society Meeting, Rhodes Island, Greece, 13 Sep - 18 Sep, 2009. Presentation Type: Poster Presentation Topic: Poster presentations Citation: Moricz K, Gigler G, Kompagne H, Kertesz S, Agoston M, Nagy K, Barkoczy J, Szenasi G and Gacsalyi I (2009). Antipsychotic property of EGIS 11150 (S 36549) in phencyclidine-induced disruption of prepulse inhibition in rats and mice. Conference Abstract: 41st European Brain and Behaviour Society Meeting. doi: 10.3389/conf.neuro.08.2009.09.239 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 11 Jun 2009; Published Online: 11 Jun 2009. * Correspondence: Krisztina Moricz, EGIS Pharmaceuticals Plc., CTCN, Budapest, Hungary, moricz.krisztina@egis.hu Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Krisztina Moricz Gabor Gigler Hajnalka Kompagne Szabolcs Kertesz Marta Agoston Katalin Nagy Jozsef Barkoczy Gabor Szenasi Istvan Gacsalyi Google Krisztina Moricz Gabor Gigler Hajnalka Kompagne Szabolcs Kertesz Marta Agoston Katalin Nagy Jozsef Barkoczy Gabor Szenasi Istvan Gacsalyi Google Scholar Krisztina Moricz Gabor Gigler Hajnalka Kompagne Szabolcs Kertesz Marta Agoston Katalin Nagy Jozsef Barkoczy Gabor Szenasi Istvan Gacsalyi PubMed Krisztina Moricz Gabor Gigler Hajnalka Kompagne Szabolcs Kertesz Marta Agoston Katalin Nagy Jozsef Barkoczy Gabor Szenasi Istvan Gacsalyi Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.