Abstract
In a study of the efficacy and safety of remoxipride compared with haloperidol in schizophrenia (DSM 111 R criteria), EEG frequencies were mapped before and after six weeks of medication. To be reported here, EEG changes had to reach statistical significance of t-scores of 3 or more and had to be present in both eyes-closed and eyes-open recordings. Delta (0.5-3.5 Hz) did not change significantly. Theta (4.0-7.5 Hz) decreased in the left anterior temporal, right frontal and right parietal lobes. Alpha (8.0-11.5) decreased in the right anterior temporal, left posterior temporal and right occipital lobes. Beta1 (12.0-15.5 Hz), beta2 (16-19.5 Hz) and beta3 (20.0-23.5 Hz) all decreased in the left posterior temporal lobe. Beta2 and 3 also decreased in the occipital lobes. Morstyn et al (1983) reported that in schizophrenia: (1) slow activity was increased anteriorly; (2) fast activity was increased posteriorly and in the left anterior temporal lobe. A very similar pattern was found in our patients before treatment. Antipsychotic medication returned our patients' EEGs towards normal. © 1994 American College of europsychopharmacology
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