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Abstract
The antileishmanial and antimalarial activities of different fractions of Vincetoxicum stocksii, Carum copticum, Gentiana olivierii and Zygophyllum fabago were determined. Amongst these, V. stocksii and C. copticum showed moderate to good antimalarial activity. The ethyl acetate fractions of C. copticum and hexane fraction of V. stocksii showed 94 % and 52% inhibition of Plasmodium falciparum (D6 Clone) respectively. The hexane ethyl acetate fraction of C. copticum and V. stocksi exhibited antileishmanial activity against, Leishmania donovani promastigotes with IC 50 of 30 µg/mL and 51 mg/mL, respectively.
Highlights
The parasitic diseases such as malaria and leishmaniasis have a high death rate in developing countries
G. olivieri is used in traditional use folk medicine for the treatment of skin diseases, abscesses, ulcer, blood pressure (Mansoor et al, 1998) and fever caused by malaria
The extracts of C. copticum and V. stocksii showed moderate to mild antileishmanial activities with IC90 values of 60 and 70 μg/mL respectively
Summary
The parasitic diseases such as malaria and leishmaniasis have a high death rate in developing countries. In this paper the antimalarial and antileishmanial effects of these four medicinal plants were determined. The whole plant of C. copticum, V. stocksii, G. olivieri and Z. fabago (2 kg each) were collected in June 2006 from the mountains of Quetta. Concentrated under reduced pressure in a rotary evaporator at 40oC, to obtain thick crude extract, which yielded C. copticum (23.4 g), V. stocksii (20.7 g), G. olivieri (27.5 g) and Z. fabago (22.8 g).
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