Abstract
Alkaloids, a category of natural products with ring structures and nitrogen atoms, include most U.S. Food and Drug Administration approved plant derived anti-cancer agents. Evodiamine is an alkaloid with attractive multitargeting antiproliferative activity. Its high content in the natural source ensures its adequate supply on the market and guarantees further medicinal study. To the best of our knowledge, there is no systematic review about the antiproliferative effects of evodiamine derivatives. Therefore, in this article the review of the antiproliferative activities of evodiamine will be updated. More importantly, the antiproliferative activities of structurally modified new analogues of evodiamine will be summarized for the first time.
Highlights
Nature derived compounds are important for therapeutic leads [1,2,3,4,5,6,7]
Evodiamine focusing on antiproliferative activities and molecular mechanisms have by Jiang
By inactivating mammalian target of rapamycin/p70 of tube-like structures by human umbilical vein endothelial cells (HUVECs), while conditioned ribosomal S6 kinase 1/Mcl-1 pathway, evodiamine and erlotinib acted in medium produced from evodiamine-pretreated CL1 cells exerted low ability of inducing capillary synergy in inhibiting cell proliferation and increasing apoptosis in non-small cell lung cancer (NSCLC) cells
Summary
For anti-cancer agents, more than half cancer chemotherapy drugs are natural products and their derivatives [8,9,10]. Most U.S Food and Drug Administration approved plant derived anti-cancer agents are alkaloids, including vincristine, paclitaxel, and homoharringtonine. Evodiamine (1, Figure 1) is a famous alkaloid with a quinazolinocarboline skeleton It was isolated from Evodia rutaecarpa, the dried and nearly ripe fruits of Euodia rutaecarpa (Juss.) Benth., E. rutaecarpa (Juss.) Benth var. Evodiamine focusing on antiproliferative activities and molecular mechanisms have been reviewed. Evodiamine focusing on antiproliferative activities and molecular mechanisms have by Jiang. There systematic review about the antiproliferative antiproliferative effects effects of evodiamine evodiamine derivatives. This article article updated updated the the review review of of the about antiproliferative activities activities of of evodiamine.
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