Antiproliferative effects, apoptosis induction and cell cycle alterations by trail and Berberin in MCF7 and MDA-MB-468 breast cancer cell lines

Abstract

The aim of this study is to document and describe important ethnobotanical features of 14 villages of Turgutlu (Manisa – Turkey).The regular ethnobotanical surveys were carried out during different seasons in the years 2009 and 2010 in 14 villages of Turgutlu. The data was collected from 91 village inhabitants using semi-structured interviews. Use value (UV) was used to calculate the relative importance of species known by the inhabitants. Informant Consensus Factor (FIC) was used to calculate the level of homogeneity of diseases.Twenty-nine plant families and 54 plant species were found in this ethnobotanical survey. Among them, 22 (40.7%) species were wild and 32 (59.3%) species were cultivated plants. Rosaceae (14.8%), Asteraceae (9.3%), Lamiaceae (9.3%), Apiaceae (5.6%) and Brassicaceae (5.6%) were the most common plant families. According to results of the use value (UV) calculations, Agropyron repens (L.) P.Beauv., Lactuca sativa L., Beta vulgaris L. var. crassa (Alef.) Helm, Spinacia oleracea L., Brassica nigra (L.) Koch, Capsella bursa-pastoris L. and Eugenia caryophyllata Thunb. yielded the highest use value. Consensus Informants Factor (FIC) ranges were between 0.87 and 0.95. Blood disorders, wounds, dermatological diseases and chest infections were 0.95, 0.93, 0.92, 0.90 while both gastrointestinal and skeletomuscular ailments were 0.87 informant consensus values, respectively.The usage of medicinal plants for traditional healers is still popular among the inhabitants of the village. This study documents valuable information for traditional remedies and contributes to the usage of medicinal plants in the research area.