Abstract
Abstract Objectives Recently, phenolic compounds (quercetin, kaempferol, ellagic acid (EA), and myricetin) as natural sources have been suggested to be used for treatment and chemoprevention of prostate cancer. Since rosehip includes the above molecules in high concentration, we set out to investigate possible anti-proliferative effect of rosehip tea on the prostate cancer cell line. Methods The flavonol content of rosehip tea prepared at different temperatures and time intervals was determined first and then the antiproliferative effect of tea samples was established by adding tea samples to the prostate cancer cell line (VCaP and LNCaP). Results Quercetin was more effective in LNCaP cell than in VCaP cell (IC50 = 20 and 200 μM, respectively). The boiled fruit shredded at minute 7 showed the highest levels of quercetin, EA and kaempferol and the boiled fruit at minute 7 had the highest levels of kaempferol and EA. The tea samples were prepared in concentrations relevant to their IC50 values, added to the VCaP and LNCaP cell lines. The antiproliferative effect of rosehip tea on VCaP cells was slightly greater than that of LNCaP cells. Conclusion Each of the flavonols exhibits an antiproliferative effect. Our data clearly indicated that rosehip as a natural source of all flavonols had an antiproliferative effect on androgen-sensitive prostate cancer. Now that it is important to use natural sources in cancer, rosehip seems to be a promising natural product to be used to treat the prostate illness.
Highlights
Materials and methodsProstate cancer is the second most common type of cancer in the world after lung cancer [1,2,3]
The flavonol content of rosehip tea prepared at different temperatures and time intervals was determined first and the antiproliferative effect of tea samples was established by adding tea samples to the prostate cancer cell line (VCaP and LNCaP)
Our data clearly indicated that rosehip as a natural source of all flavonols had an antiproliferative effect on androgen-sensitive prostate cancer
Summary
Prostate cancer is the second most common type of cancer in the world after lung cancer [1,2,3]. Androgen and androgen receptors have been demonstrated to induce the development and progression of cancer. Current treatment protocols have focused on reducing androgen and androgen receptors [1]. Recent studies have shown that diet with phenolic acid is associated with a lower risk of prostate cancer [4, 5]. Especially the most common type Rosa canina is cultivated in the Aegean region of Turkey. Rosehips have been proven to have antiproliferative properties against different types of cancer due to its content of vitamin C and E and phenolic compounds [7, 8]
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