Abstract
Antiproliferative and cytotoxic efficacies of the phospholipids OPP and HPC were compared in a panel of 10 human and rat tumor cell lines. The dose ranges were similar for the inhibition of cell growth measured by ID50 and for the cytotoxic effect (LD(50)). The ratios of LD(50)/ID50 revealed variations between the individual cell lines. After initial inhibition by twice the ID50 complete recovery of proliferation was observed in OPP withdrawal experiments. Cultivation in the continuous presence of OPP resulted in the recovery of proliferation in 3 of 5 cell lines tested, apparently based on resistant subpopulations.
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