Antiproliferative and Antimicrobial Effects of Tris(2-hydroxyethyl)ammonium-Based Protic Ionic Liquids with Some Fatty Acids

Abstract

Protic ionic liquids (PILs) that emerge as promising compounds are of great interest in industry and academia due to their easy synthesis and unique physical and chemical properties. This study aims to evaluate the antimicrobial activities against various microorganisms and the antiproliferative effects of four PILs namely, the PILs tris(2-hydroxyethyl)ammonium dodecanoate (TALA), tris(2-hydroxyethyl)ammonium tetradecanoate (TAMA), tris(2-hydroxyethyl)ammonium palmitate (TAPA) and tris(2-hydroxyethyl)ammonium stearate (TASA). Antiproliferative effects of PILs were investigated in vitro on breast cancer cell line (MDA-MB 231), colon cancer cell line (HT29) and prostate cancer cell line (PC3). Furthermore, minimum inhibitory concentrations (MIC) were established for PILs tested against rods, cocci and fungi. The antimicrobial activities of the PILs are strongly related to the alkyl chain length of the anion.