Abstract
Trithiolato-bridged arene osmium complexes of the general formula [(p-cymene)2Os2(μ-SR)3]+ (R=C6H5, [1]+; C6H4-p-Me, [2]+; C6H4-p-OMe, [3]+; C6H4-p-Pri, [4]+; C6H4-p-But, [5]+; CH2C6H5, [6]+; CH2CH2C6H5, [7]+; CH2C6H4-p-But, [8]+) were synthesized in ethanol by reacting the p-cymene osmium dimer [(p-cymene)2Os2(μ-Cl)2Cl2] with the corresponding thiol (RSH). The complexes were isolated as their chloride salts, and fully characterized by spectroscopic methods. The single-crystal X-ray structure analysis of the salt [6]Cl is also presented. These osmium complexes were found to be highly cytotoxic towards several cancerous cell lines (A2780, A549, B16F10, HeLa) with IC50 values comparable or even better to those found for doxorubicin.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.