Abstract
Bioassay-directed fractionation of the stems of Rollinia mucosa led to the isolation of new N-methoxycarbonyl aporphine alkaloids, romucosine A ( 1), romucosine B ( 2), romucosine C ( 3), and romucosine D ( 4), along with the known alkaloid, N-methoxylcarbonyl-nornuciferine ( 5). Alkaloids 1 and 4 exhibited significant inhibition of collagen, arachidonic acid, and platelet activating factor-induced platelet aggregation, and alkaloid 3 also showed an inhibitory effect on arachidonic acid induced platelet aggregation.
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