Antiplasmodial and larvicidal compounds of Toddalia asiatica root bark

Abstract

From the n-hexane, ethyl acetate and methanol extracts of Toddalia asiatica root bark were isolated eight compounds (1–8) which were identified on the basis of both spectroscopic and physical data as well as comparison with already published results. The crude extracts and isolated compounds showed moderate in vitro antiplasmodial activity against D6 (chloroquine-sensitive) and W2 (chloroquine-resistant) strains of Plasmodium falciparum. The extracts and isolates also exhibited larvicidal activities against Aedes aegypti and coumarins were identified as the active compounds. Chemical examination of Toddalia asiatica root bark resulted into the isolation of eight compounds which were evaluated for antiplasmodial and larvicidal activities. Toddaculatin (3) was the most active against chloroquine sensitive D6 strain of Plasmodium falciparum while toddanol (6) was found to be toxic against Aedes aegyti 2nd instar larvae.