Abstract
Mimusops caffra E. Mey. ex A.DC., Mimusops obtusifolia, Lam (both members of Sapotaceae family) and Hpoxis colchicifolia, Bak are used by traditional healers in Zululand to manage malaria. We have investigated the anti-plasmodial activity of the crude extracts and isolated pure compounds of these plants. The crude dichloromethane extracts of the plants showed activity against the chloroquine sensitive (CQS) strain of Plasmodium falciparum (D10). The crude plants extracts exhibited activity with IC50 values raging from 2.14 µg/ml to 32.5 µg/ml. The pentacyclic triterpenoids (PTCs) isolated and characterized (through IR, NMR, MS spectral data) from the leaves and stem bark of M. caffra and M. obtusifolia include taraxerol (I), Sawamilletin (II), and ursolic acid (III). Ursolic acid was found to have anti-plasmodial activity (IC50, 6.8 µg/ml). The results validate the use of these plants in folk medicine.
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