Abstract
The antiplasmodial effect of ethanolic leaf extract of Phyllanthus amarus on the biomarkers of renal function was investigated. The phytochemical constituents of the extract were screened. The renal function markers investigated include levels of uric acid, creatinine, urea and electrolytes (HCO 3 , Na + , K + and Cl ) in serum of Plasmodium berghei infected mice treated with P. amarus. Twenty-five (25) adult mice (22-27g bwt) randomly divided into 5 groups (n= 5/grp) were used. Group 1; Normal control (uninfected and untreated), Group 2; malarial control (infected with P. berghei and untreated), Group 3; infected and treated with Pyllanthus amarus leaf extract (200mg/kg bwt), Group 4; uninfected but treated with same dose of Phyllanthus amarus and Group 5; standard control (infected and treated with quinine, 5mg/kg). Each group was so treated for 5 days and on the 6 th day the animals were sacrificed under chloroform anaesthesia after an overnight fast. Whole blood samples were obtained by cardiac puncture and then, prepared for biochemical assay using standard methods. Results show that P. berghei malaria infection significantly ( p<0.05) increases
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