Abstract
Objectives:The antiplaque and antigingivitis effect of Lippia Sidoides (LS) was evaluated in this in vivo investigation.Material and Methods:Twenty-three subjects participated in a cross-over, double-blind clinical study, using 21-day partial-mouth experimental model of gingivitis. A toothshield was constructed for each volunteer, avoiding the brushing of the 4 experimental posterior teeth in the lower left quadrant. The subjects were randomly assigned initially to use either the placebo gel (control group) or the test gel, containing 10% LS (test group).Results:The clinical results showed statistically significant differences for plaque index (PLI) (p<0.01) between days 0 and 21 in both groups, however only the control group showed statistically significant difference (p<0.01) for the bleeding (IB) and gingival (GI) index within the experimental period of 21 days. On day 21, the test group presented significantly better results than the control group with regard to the GI (p<0.05).Conclusions:The test gel containing 10% LS was effective in the control of gingivitis.
Highlights
Gingivitis is one of the most frequent periodontal diseases, affecting more than 90% of the population, regardless of age, sex or race[21]
After 10 to 21 days of supragingival dental plaque accumulation, clinical signs of gingivitis appear, such as redness, edema and a tendency to marginal bleeding on gentle probing[20]
On day 0 the control and test groups did not show statistically significant difference from each other with respect to plaque index (PLI) (p=0.9813), Bleeding Index (BI) (p=0.4455) and GI (p=0.4455) means. These results indicated that both groups were well balanced at baseline (Tables 1, 2 and 3)
Summary
Gingivitis is one of the most frequent periodontal diseases, affecting more than 90% of the population, regardless of age, sex or race[21]. Brazilian epidemiologic studies have shown a high prevalence of gingival inflammation, ranging from 74% to 100%, media individual percent of gingival bleeding vary from 28% to 35%16. Dental plaque can be visible on dental surfaces after 1 or 2 days if oral hygiene procedures are unsatisfactory. The localization and rate of its formation are varied, depending of determinant factors such as diet and salivary flow[20]. After 10 to 21 days of supragingival dental plaque accumulation, clinical signs of gingivitis appear, such as redness, edema and a tendency to marginal bleeding on gentle probing[20]. Chemotherapeutic agents had been used as antiplaque agent, avoiding development of gingivitis[13]. Due to undesirable effects after prolonged use, such as pigmentation and taste disturbance[11], phytotherapic agents have been investigated as alternatives[4,6,14,16]
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