Abstract
BMAL1 is a putative transcription factor which is involved in circadian rhythm generation inDrosophila.Northern blot analysis was performed to investigate the expression of ratBMAL1mRNA in the suprachiasmatic nucleus (SCN) and peripheral tissues. In the SCN, circadian expression ofBMAL1mRNA which reaches its peak level at the time of dark–light transition was observed, and the expression pattern was antiphase to those of twoperiod(per) homologues,rPer1andrPer2.However, no circadian oscillation for ratClockmRNA was detected. The circadian expression ofBMAL1mRNA was also observed in peripheral tissues such as brain (excluding the SCN), eye, heart, kidney, and lung. The amplitudes ofBMAL1andrPer2mRNA expression levels were correlated between the different tissues, suggesting that the circadian expression ofBMAL1mRNA plays an important role in generating the circadian expression ofperhomologue genes in mammals.
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