Abstract
AbstractThe site at which pentylenetetrazol (PTZ) and diazepam interact was explored. Neither Ro (15‐1788, a benzodiazepine DZ) receptor antagonist, nor 4,5,6,7‐tetrahydroisoxagolo (5,4‐c) pyridin‐3‐ol, (THIP), a γ‐aminobutyric acid (GABAA) receptor ligand, alone had any effect on the incidence of PTZ‐induced seizures. Ro 15‐1788 inhibited the anti‐PTZ activity of diazepam but not that of pentobarbital. THIP had no effect on the anti‐PTZ activity of diazepam even after toxic doses. Combination studies with diazepam and progabide (GABAA receptor ligand) or diazepam and pentobarbital demonstrate that the anti‐PTZ activity of the individual components interact additively. These results imply that (GABA‐independent BDZ receptors contribute to the anti‐PTZ action of BDZs).
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