Antiparasitic activity in Asteraceae with special attention to ethnobotanical use by the tribes of Odisha, India.

Sujogya Kumar Panda,Walter Luyten

doi:10.1051/parasite/2018008

Abstract

The purpose of this review is to survey the antiparasitic plants of the Asteraceae family and their applicability in the treatment of parasites. This review is divided into three major parts: (a) literature on traditional uses of Asteraceae plants for the treatment of parasites; (b) description of the major classes of chemical compounds from Asteraceae and their antiparasitic effects; and (c) antiparasitic activity with special reference to flavonoids and terpenoids. This review provides detailed information on the reported Asteraceae plant extracts found throughout the world and on isolated secondary metabolites that can inhibit protozoan parasites such as Plasmodium, Trypanosoma, Leishmania, and intestinal worms. Additionally, special attention is given to the Asteraceae plants of Odisha, used by the tribes of the area as antiparasitics. These plants are compared to the same plants used traditionally in other regions. Finally, we provide information on which plants identified in Odisha, India and related compounds show promise for the development of new drugs against parasitic diseases. For most of the plants discussed in this review, the active compounds still need to be isolated and tested further.

Highlights

À Antiparasitic researchParasite diseases are a major source of disease in both humans and animals and result in significant economic losses
The 2015 Nobel Prize in Physiology or Medicine was awarded for the discovery of artemisinin and avermectin, which fundamentally changed the treatment of parasitic diseases around the globe
A breakthrough for the development of antimalarial drugs was the identification of the sesquiterpene artemisinin from Artemisia annua (Asteraceae), which can even kill multidrug-resistant strains of Plasmodium falciparum [3,62]

Summary

Introduction

À Antiparasitic researchParasite diseases are a major source of disease in both humans and animals and result in significant economic losses. Protozoan parasites threaten the lives of billions of. The 2015 Nobel Prize in Physiology or Medicine was awarded for the discovery of artemisinin and avermectin, which fundamentally changed the treatment of parasitic diseases around the globe. Both compounds are natural products, once again showing that nature can be a powerful source of medicines. Several semisynthetic derivatives of artemisinin (e.g., the water-soluble artesunate) have been developed and are used in clinical practice today [62]

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