Abstract
Myrcia bella Cambess., Myrcia fallax (Rich.) DC. and Myrcia guianensis (Aubl.) DC. (Myrtaceae) are trees found in Brazilian Cerrado. They have been widely used in folk medicine for the treatment of gastrointestinal disorders, hemorrhagic and infectious diseases. Few reports have been found in the literature connecting their phenolic composition and biological activities. In this regard, we have profiled the main phenolic constituents of Myrcia spp. leaves extracts by ESI(−)Q-TOF-MS. The main constituents found were ellagic acid (M. bella), galloyl glucose isomers (M. guianensis) and hexahydroxydiphenic (HHDP) acid derivatives (M. fallax). In addition, quercetin and myricetin derivatives were also found in all Myrcia spp. extracts. The most promising antioxidant activity, measured by 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity, was found for M. fallax extracts (EC50 8.61 ± 0.22 µg·mL−1), being slightly less active than quercetin and gallic acid (EC50 2.96 ± 0.17 and 2.03 ± 0.02 µg·mL−1, respectively). For in vitro antiproliferative activity, M. guianensis showed good activity against leukemia (K562 TGI = 7.45 µg·mL−1). The best antimicrobial activity was observed for M. bella and M. fallax to Escherichia coli (300 and 250 µg·mL−1, respectively). In conclusion, the activities found are closely related to the phenolic composition of these plants.
Highlights
The Myrtaceae family is one of the most important genera of the wet tropics, including SouthAmerica, Australia and Tropical Asia
We report the rapid characterization of the main phenolic compounds from the hydroethanolic extracts of three different Myrtaceae leaves: Myrcia bella Cambess., Myrcia fallax (Rich.) DC. and Myrcia guianensis (Aubl.) DC., using Electrospray Ionization Quadropole Time-of-Flight
This research shows the main polyphenolic compounds identified from Myrcia bella
Summary
The Myrtaceae family is one of the most important genera of the wet tropics, including South. Experimental studies have associated oxidative cellular damage arising from an imbalance between free radical generation and scavenging systems as the primary cause of cardiovascular disease, cancer and aging. Direct infusion electrospray ionization high resolution mass spectrometry (ESI-HRMS) has been used for this purpose, because does not require exhaustive sampling preparation for analysis. This method allows the identification of complex organic mixtures without prior extraction or separation steps. We have already applied ESI-HRMS with success in the phenolic fingerprinting studies of Stryphnodrendon obovatum extracts [1] In this context, we report the rapid characterization of the main phenolic compounds from the hydroethanolic extracts of three different Myrtaceae leaves: Myrcia bella Cambess., Myrcia fallax (Rich.) DC. A correlation between the compounds identified by ESI(−)-MS and the antioxidant, antiproliferative, and antimicrobial activities was established after in vitro analysis
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
