Abstract
Oxidative stress plays an important role in the pathogenesis of myocardial infarction (MI). Schisandra chinensis bee pollen extract (SCBPE) possesses powerful antioxidant capacity. This study aimed to further explore the antioxidative and cardioprotective effects of SCBPE on acute MI induced by isoprenaline (ISO) in rats. The rats were intragastrically administrated with SCBPE (600, 1200, or 1800 mg/kg/day) and Compound Danshen dropping pills (270 mg/kg/day) for 30 days, then subcutaneously injected with ISO (65 mg/kg/day) on the 29th and 30th day. Compared with the model group, pretreatment with middle and high doses of SCBPE significantly reduced serum aspartate transaminase, lactate dehydrogenase, and creatine kinase activities and increased myocardial superoxide dismutase, glutathione peroxidase, and catalase activities. The histopathologic aspects showed that pathological heart change was found in the model group and reduced to varying degrees in the SCBPE groups. Moreover, the protein expression of nuclear factor-erythroid 2-related factor 2 (Nrf-2), heme oxygenase-1 (HO-1), and Bcl2 in the heart increased in the SCBPE groups, while that of Bax decreased compared to the model group. Besides this, uridine was isolated from S. chinensis bee pollen for the first time. This study could provide a scientific basis for using Schisandra chinensis bee pollen as a functional food for the prevention of MI.
Highlights
Myocardial infarction (MI) is a major cause of death and disability worldwide; it may be the first manifestation of coronary artery disease or it may occur repeatedly in patients with established disease [1]
10.99 and 11.71 min, which was isolated from S. chinensis bee pollen for the first time
We observed a significant increase in myocardial heme oxygenase-1 (HO-1) expression in Schisandra chinensis bee pollen extract (SCBPE)-pretreated rats compared with in the model group
Summary
Myocardial infarction (MI) is a major cause of death and disability worldwide; it may be the first manifestation of coronary artery disease or it may occur repeatedly in patients with established disease [1]. Overproduction of reactive oxygen species (ROS) may affect cell membrane properties and cause oxidative damage to nucleic acids, lipids, and proteins that may make them nonfunctional. Isoprenaline (ISO), a synthetic catecholamine and β-adrenergic receptor agonist, has been reported to induce infarct-like myocardial lesions under subcutaneous administration [4]. The cardiotoxicity induced by high levels of ISO is mediated by vasospasticity, combined with increased oxygen demand due to its positive inotropic effect, and is related to the oxidative stress [5,6,7]
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