Abstract
The inhibiting effect of melanin synthesized from dihydroxyphenylalanine (DOPA), dopamine, adrenaline and adrenolutin on the ultraviolet- or the Fe 2+-ascorbic acid-induced lipid peroxidation. Antioxidative activity of melanins enhances in the order: dopamine-melanin<melanin synthesized from dopamine in the presence of Cu 2+ < DOPA - melanin < melanin synthetized from adrenaline in the presence of Cu 2+ ⋟ adrenolutin-melanin , and correlates with thei ability to scavenge superoxide anion radical. The optical screening effect of the investigated melanins in the inhibition of lipid peroxidation was not higher than 15% for the most active melanins.
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Schedule a callMore From: Biochimica et Biophysica Acta (BBA) - General Subjects
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