Antioxidation Role of Different Lateral Stellate Ganglion Block in Isoproterenol-Induced Acute Myocardial Ischemia in Rats.

Abstract

To determine whether stellate ganglion block (SGB) treatment exerts protective effects against isoproterenol (ISO)-induced acute myocardial ischemia (AMI) due to its antioxidant effects, we aimed to evaluate the protective effects of different lateral SGB agents on the tissue antioxidant status in ISO-induced AMI in male Sprague-Dawley rats. The AMI model received an acute ISO overdose to make cardiac ischemia damage at a single dose of 110 mg/kg injected subcutaneously into the rats. The rats in the SGB groups received SGB 15 minutes after ISO treatment. The data were recorded at the following time points: 0 minutes (T0) and 15 minutes after SGB (T1). The levels of cardiac troponin T and cardiac troponin I and the ST-segment depression in lead III were measured at T0 and T1. The values of oxidative production and antioxidative enzymes in the SG and heart were tested. Stellate ganglion block significantly reduced serum cardiac troponin I and cardiac troponin T levels and mitigated the ST-segment depression and oxidative production levels, but it increased the antioxidative enzymes levels. Right SGB effect was more effective than that of left SGB, in the reduced nitric oxide and malonaldehyde levels, and in the increased superoxide dismutase, glutathione peroxidase, catalase, neuronal nitric oxide synthase, and endothelial nitric oxide synthase levels. These findings suggest that SGB could have antioxidative effects against AMI, and the protective effect of right SGB was more effective than that of left SGB. Thus, the right SGB could be an effective and safe method of local anesthesia to protect against cardiac damage due to oxidative stress.