Abstract
Objective: Endometriosis has been referred to an inflammatory disease in the peritoneal cavity and a number of inflammatory genes have been recognized to be induced by oxidative stress and attenuated by antioxidants. Our previous study has shown that co-culture of endometrial cells with mesothelial cells resulted in significant high-level productions of MCP-1 and other cytokines. Therefore, it is important to determine whether the induction of MCP-1 by endometrial cells when added to the mesothelial cells involves an oxidative stress and whether the addition of antioxidants would decrease MCP-1 gene expression. The object of this study is to determine whether antioxidants have effects on the production of MCP-1 in the inflammatory reaction induced by co-culturing of endometrial cells with mesothelial cells.
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