Abstract
Objective: Regulation of growth and apoptosis of ovarian mesenchyme is essential for normal ovarian development and homeostasis. Hyperplasia of ovarian mesenchyme is encountered in pathological conditions, such as polycystic ovary syndrome (PCOS) and hyperthecosis. These conditions are associated with insulin resistance and hyperinsulinemia. Other hyperinsulinemic states, such as syndrome X and type 2 diabetes mellitus are characterized by excessive oxidative stress. We have recently reported that oxidative stress stimulates growth of ovarian thecal-interstitial cells raising the possibility that excessive oxidative stress may contribute to thecal-interstitial hyperplasia. This study tested the hypothesis that antioxidants extinguish reactive oxygen species and limit growth by inducing apoptosis.
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