Abstract
Main Results Children randomized to antioxidant supplements attained similar developmental outcomes to those without antioxidants (mean Griffiths developmental quotient 57.3 v 56.1; adjusted mean difference 1.2 points, 95% confidence interval 2.2 to 4.6). Comparison of children randomized to folinic acid supplements or no folinic acid also showed no significant differences in Griffiths developmental quotient (mean 57.6 v 55.9; adjusted mean difference 1.7, 1.7 to 5.1). No between group differences were seen in the mean numbers of words said or signed: for antioxidants versus none, the ratio of means was 0.85 (95% confidence interval 0.6 to 1.2), and, for folinic acid versus none, it was 1.24 (0.87 to 1.77). No significant differences were found between any of the groups in the biochemical outcomes measured. Adjustment for potential confounders did not appreciably change the results.
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