Abstract
Acute respiratory distress syndrome (ARDS) is a major cause of patient mortality in intensive care units (ICUs) worldwide. Considering that no causative treatment but only symptomatic care is available, it is obvious that there is a high unmet medical need for a new therapeutic concept. One reason for a missing etiologic therapy strategy is the multifactorial origin of ARDS, which leads to a large heterogeneity of patients. This review summarizes the various kinds of ARDS onset with a special focus on the role of reactive oxygen species (ROS), which are generally linked to ARDS development and progression. Taking a closer look at the data which already have been established in mouse models, this review finally proposes the translation of these results on successful antioxidant use in a personalized approach to the ICU patient as a potential adjuvant to standard ARDS treatment.
Highlights
Syndrome (ARDS) Treatment—FromAcute respiratory distress syndrome (ARDS) was originally described by Ashbaugh et al.in 1967 [1]
An acute onset as well as bilateral infiltrates detected by a frontal chest radiograph and a pulmonary artery wedge pressure of above 18 mm Hg or missing evidence of left atrial hypertension were set as common characteristics
Two reviews summarizedpharmacological pharmacological treatments treatments for Recently, two reviews summarized for patients patients suffersuffering ing from ARDS [232,233]
Summary
Acute respiratory distress syndrome (ARDS) was originally described by Ashbaugh et al. Defined characteristics were hypoxemia with PaO2 /FiO2 < 200 mm Hg and PEEP ≥ 10 mm Hg, acute onset in
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