Abstract
The aim of this study was to investigate whether there was any difference in the levels of antioxidant agents in the immune system between essential hypertension in pregnancy and pregnancy-induced hypertension (PIH). The functions of T and B lymphocytes were analysed by lymphocyte response to mitogens and the ability to secrete immunoglobulins, respectively. Interleukin-2 (IL-2) production from lymphocytes was also determined by bioassay. Five antioxidant agents–superoxide dismutase (SOD), plasma thiol (PSH), red cell lysate thiol (LSH), plasma glutathione (GSHp) and red cell membrane thiol (MSH)–were measured enzymatically and spectrophotometrically. The results showed that there was no significant difference in mitogenic activity between normal pregnancy and essential hypertension. However, phytohaemagglutinin-induced mitogenic activity was increased in patients with PIH compared to patients with essential hypertension and normal pregnancy. IL-2 production in patients with PIH was also significantly hig...
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