Abstract
BackgroundThe goal of our study is to evaluate the effects of antioxidant vitamins (vitamin C and E), Coenzyme Q10 (CoQ10) and dexamethasone (Dxm) in experimental rat models with pulmonary contusion (PC).MethodsRats were randomly divided into six groups. Except for the control, all subgroups had a moderate pulmonary contusion. Animals in the group I and group II received intraperitoneal saline, group III received 10mg.kg-1 CoQ10 group IV received 100mg.kg-1 vitamin C, group V received 150mg.kg-1 vitamin E, and group VI received 10mg.kg-1 Dxm. Blood gas analysis, serum nitric oxide (NO) and malondialdehyde (MDA) levels as well as superoxide dismutase (SOD) activity assays, bronchoalveolar lavage (BAL) fluid and histopathological examination were performed.ResultsAdministration of CoQ10 resulted in a significant increase in PaO2 values compared with the group I (p = 0.004). Levels of plasma MDA in group II were significantly higher than those in the group I (p = 0.01). Early administration of vitamin C, CoQ10, and Dxm significantly decreased the levels of MDA (p = 0.01). Lung contusion due to blunt trauma significantly decreased SOD activities in rat lung tissue compared with group I (p = 0.01). SOD levels were significantly elevated in animals treated with CoQ10, Vitamin E, or Dxm compared with group II (p = 0.01).ConclusionsIn our study, CoQ10, vitamin C, vitamin E and Dxm had a protective effect on the biochemical and histopathological outcome of PC after experimental blunt thorax trauma.
Highlights
The goal of our study is to evaluate the effects of antioxidant vitamins, Coenzyme Q10 (CoQ10) and dexamethasone (Dxm) in experimental rat models with pulmonary contusion (PC)
Animals After the study was approved by the Animal Ethics Committee of Zonguldak Karaelmas University (ZKU) Medical School, 42 adult male Wistar–Albino rats weighting 450-550 g were randomly divided into six groups
Of the 42 animals subjected to blunt chest trauma, none of the rats died during the experiment
Summary
The goal of our study is to evaluate the effects of antioxidant vitamins (vitamin C and E), Coenzyme Q10 (CoQ10) and dexamethasone (Dxm) in experimental rat models with pulmonary contusion (PC). Pulmonary contusion (PC) is the most frequently diagnosed intrathoracic injury related to blunt chest trauma, affecting 17-25% of adult blunt chest trauma patients [1,2]. It is an independent risk factor for the development of pneumonia, severe clinical acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) [1]. The antioxidant drug TempolW, antioxidant effectivity N-acetyl cystein (NAC) and dexamethasone (Dxm) were used in experimental PC models [13,16]
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