Abstract
Sickle cell anaemia is one of the commonest causes of anaemia in sub-Saharan Africa. It causes significant morbidity and mortality, commoner in black Africa, but due to increase medical care, the life expectancy is on increase. Several studies have been carried out on sickle cell anaemia (SCA) nationally and internationally. This present study determined the BMI of SCA patients in the steady state compared to normal control in the north-eastern Nigeria. A cross-sectional study was carried out at the University of Maiduguri Teaching Hospital (UMTH) as a referral center. Undergraduate students, secondary and primary school students of the University of Maiduguri Borno state were incorporated in the study as controls. A total number of 120 subjects were enrolled into the study constituting 60 subjects with homozygous SS, and 60 controls who are homozygous AA. Random sampling technique was employed in the selection of the subjects that attends the sickle cell haematology clinics both in adults and paediatrics that were at their steady state. BMI of the SCA were found to be either normal weight (18.5-24.9kg/m2) or underweight ( 29.9kg/m2) in addition to underweight and normal weight. Antioxidant vitamins A and E were also found to be low in SCA patients compared to the normal controls In conclusion, we therefore concluded that overweight and obese is very rare in patients with sickle cell anaemia.
Highlights
Sickle cell disease (SCD) is an inherited disorder of haemoglobin synthesis that is associated with significant morbidity and mortality due to sequelae of episodic vasoocclusive events: pain crisis and multi organ damage [1]
A total number of 120 subjects were enrolled into the study constituting 60 subjects with sickle cell anaemia who were in the steady state, and 60 controls who were homozygous AA, of both sexes with age range between 1.3 to 35 years
The results from this study showed that Sickle cell aneamia (SCA) subjects have underweight and normal weight while the control group in addition have overweight and obese
Summary
Sickle cell disease (SCD) is an inherited disorder of haemoglobin synthesis that is associated with significant morbidity and mortality due to sequelae of episodic vasoocclusive events: pain crisis and multi organ damage [1]. Sickle cell aneamia (SCA) results from the substitution of valine residue for glutamic acid at position 6 of the beta sub unit haemoglobin [2]. People with only one gene for HbS are phenotypically normal (sickle cell trait) [3] while those who inherited two HbS genes from both parents have SCA. In Nigeria, heterozygous (AS) carrier rates is about 25% in the south and 18-32.6% in the North. In the North East the highest frequencies of Hb AS have been recorded among the Kanuris, (27.9%) of Borno state and Bades (32.67%) of Yobe
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