Abstract
Objective: This is a retrospective study to evaluate the effect of using the antioxidants containing coenzyme Q10 (CoQ10) and omega-3 in patients undergoing in vitro fertilization and intracytoplasmic sperm injection (IVF-ICSI) for unexplained infertility. Materials Methods: A total of 299 patients undergoing IVF-ICSI for unexplained infertility at the IVF center of Ondokuz Mayis University were studied. The subject group consisted of 135 patients who used OMEPA Q10 (Co Q10 100 mg, omega-3 600 mg, eicosapentaenoic acid 300 mg, docosahexaenoic acid 230 mg) for two months before ovarian stimulation. A group of 164 patients who did not use the supplement were evaluated as the control group. Results: The pregnancy rate of patients using antioxidants was statistically higher than that of those who did not use the supplement (p < 0.05). The pregnancy rates of patients in the two groups were 32.9% and 49.6% respectively. The pregnancy rate of patients using antioxidants was statistically higher than that of those who did not use the supplement (p < 0.05) seemed not enough. Conclusion: We concluded that using antioxidants that contain Co Q10 and omega-3 in patients undergoing IVF-ICSI for unexplained infertility increased the clinical pregnancy rate. We recommend using antioxidants that contain Co Q10 and omega-3 in infertile patients.
Highlights
Today, despite many advances in infertility treatment, the rate of achieving live pregnancy after the first cycle of in vitro fertilization (IVF) is still around 29% [1]
This is a retrospective study to evaluate the effect of using the antioxidants containing coenzyme Q10 (CoQ10) and omega-3 in patients undergoing in vitro fertilization and intracytoplasmic sperm injection (IVF-ICSI) for unexplained infertility
Omega-3 consists of alpha-Linoleic acid (ALA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)
Summary
Despite many advances in infertility treatment, the rate of achieving live pregnancy after the first cycle of in vitro fertilization (IVF) is still around 29% [1]. Co Q10, referred to as ubiquinone, is found in the inner membrane of mitochondria [7] and helps mitochondrial energy production by providing electron transport [8] This energy production is vital for the continuation of normal reproductive function, since oocyte maturation, fertilization, and implantation of the embryo into endometrium are energy-dependent processes [9] [10]. A lack of several micronutrients was detected in patients with unexplained infertility [14] This deficiency may decrease the quality of oocytes by causing an increase of oxygen radicals in oocyte microenvironments [15]. It has been suggested that antioxidant supplements may improve the success of IVF by providing a positive effect on oocyte quality This study investigates this suggested effect of omega-3 and Co Q10 usage in order to determine whether it can improve IVF success in unexplained infertility patients
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