Abstract
Oxidative stress is considered as a major risk factor that contributes to increased lipid peroxidation and declined antioxidants in some degenerative diseases. Glycyrrhizin is widely used to cure allergic diseases due to its medicinal properties. In the present study, we evaluated the role of glycyrrhizin on lipid peroxidation and antioxidant status in the blood and nasal mucosa of allergic rhinitis (AR) mice. Mice were divided into six groups: normal control mice, model control (MC) mice, three glycyrrhizin-treated mice groups and lycopene-treated mice. Sensitization-associated increase in lipid peroxidation was observed in the blood and nasal mucosa of MC mice. Activities of antioxidant enzymes like superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), total antioxidant capacity (TAOC) and levels of glutathione (GSH) were found to be significantly decreased in the blood and nasal mucosa in MC mice when compared to normal control mice. However, normalized lipid peroxidation and antioxidant defenses were reported in the glycyrrhizin-treated and lycopene-treated mice. Moreover, glycyrrhizin treatment still enhanced IFN-γ and reduced IL-4 levels in glycyrrhizin-treated mice. These findings demonstrated that glycyrrhizin treatment enhanced the antioxidant status and decreased the incidence of free radical-induced lipid peroxidation and improved immunity activities in the blood and nasal mucosa of AR mice.
Highlights
Allergic rhinitis (AR) affects both adolescents and younger children
In allergic rhinitis (AR) mice treated with glycyrrhizin (10 mg/kg BW), sneezing and thin nasal discharge was accompanied by slightly scratching
Oxidative stress plays an important role in allergic disorders and increased levels of oxidants are considered as markers of the inflammatory process
Summary
Allergic rhinitis (AR) affects both adolescents and younger children. AR may be regarded by parents as an irritation rather than as a significant disease and is often under-diagnosed and under-treated [1]. It is recognized that AR is made up of more than the classic symptoms of sneezing, rhinorrhea, and nasal obstruction. AR is associated with impairments in how patients function in day-to-day life at home, at work, and in school [2,3]. Patients may be bothered by sleep disorders, emotional problems, impairment in activities, and social functioning [4]. As allergic AR is one of the most frequent diseases encountered in clinical practice, the cost implications to society are enormous [5]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
