Abstract
We compared the contribution of high- and low-molecular-weight antioxidants into total antioxidant activity of blood serum in children and adults. Ten serum samples from children aged from 3 months to 12 years and 6 serum samples from adults were fractionated by chromatography and antioxidant activity and the contents of transferrin and ceruloplasmin were measured in total serum and individual chromatographic fractions. It was found that total antioxidant activity of the serum from children measured in the system of yolk lipoproteins considerably surpassed that in adults. Moreover, in adults the major part in serum antioxidant activity is played by a fist identified high-molecular-weight fraction (600 kDa) and a 67 kDa fraction containing ceruloplasmin and transferrin. Serum antioxidant activity in children was determined only by the high-molecular-weight peak not containing ceruloplasmin and transferrin, which was probably due to significantly lower serum transferrin content in children compared to adults.
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