Abstract
Objective: To assess the natural bio-remediation in Hexavalent chromium (Cr VI) toxicity induced rats. Methodology: Male albino rats were given Hexavalent chromium for 42 days to demonstrate that this carcinogenic compund increased LPO while reducing SOD, GSH, GPx, and CAT levels. Rats were randomly divided into five experimental groups (n=6). Group I was a control group as they were only given with clean water to drink. Potassium dichromate 10 g/kg was given to Group II for 42 days. Group III administered with 500 mg/kg of Cucumis melo L, Group IV was administered with 500 mg/kg of Ascorbic acid and Group V was administered with 1:1 ratio of Cucumis melo L and ascorbic acid, respectively. All results were provided as mean SD for a total of 6 rats/ per each group. The significance of differences between male albino rats was determined using the Student’s t-test. At p < 0.05 and p < 0.001, differences were judged significant. Findings: Cucumis melo L. fruit aqueous extracts significantly protected rats from chromiuminduced oxidative damage. The LD50 was determined to be 500 mg/kg using the DPPH assay. As a consequence, we believe that giving fruit extracts to people can help them recover from oxidative stress-related cell damage.Novelty: The administration of chromium 6 resulted in a substantial reduction in body weight and an increase in the organ to body weight ratio. Chromium administration significantly enhanced LPO while decreasing serum levels of SOD, GSH, GPx, and CAT. Cucumis melo aqueous fruit extract was shown to be a protective agent against chromium-induced oxidative stress at a dosage of 500 mg/kg. Keywords: Chromium VI; Cucumis melo L fruit extracts; antioxidant activity; oxidant antioxidant imbalance and oxidative stress
Highlights
Antioxidant components such as phenolics, vitamins, carotenoids, and minerals are found in the fruits, which contribute to their chemopreventive potential. [1,2] All of these chemicals have been linked to a reduced chance of developing health issues such as cancer, cardiovascular disease, type 2 diabetes, and obesity.During the growth of melons, volatile and antioxidant chemicals will generate and develop.[3]
The hydroethanolic melon peel extract exhibits a 68 percent hydroxyl radical scavenging activity.[10] our present work aims to investigate the modulation of oxidant-antioxidant status by fruit extract of C. melo L. on Hexavalent chromium– induced toxicity in male albino rats
This dosage is labelled as lethal [LD50]. [Figure 2] Previous research [20] has put the scavenging activity around 50%, the current study found that entire fruit may achieve a scavenging activity of around 71 percent
Summary
During the growth of melons, volatile and antioxidant chemicals will generate and develop.[3] The ripening stage has been shown to have a significant impact on the amounts of high bioactive chemicals in fruits.[4,5] The study of bioactive chemical changes during fruit ripening is important for both human health and economic interests These findings are useful in determining how those chemicals change over time and determining the optimal harvesting period to obtain the maximum antioxidant potential. Because of its low molecular weight, hydroxycinnamic acid (caffeic, sinapic, -coumaric, and ferulic acids) is an important product of phenyl propanoid They are commonly associated with polysaccharides found in cell walls, lignin and heratsllulose units. The flavonoids are connected to the polysaccharides of the cell wall, which include lignin and heratsllulose. [6]
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