Abstract
A considerable number of studies has shown that many constituents of foods derived from plants are effective and safe antioxidants. This explains the growing interest in natural antioxidants in food applications. The goal of this investigation was to evaluate the antioxidant properties of the Vam3, a resveratrol derivative, firstly isolated from ethanol extracts of Vitis amurensis Rupr as a secondary product, and to carry out a comparison with resveratrol and other phenolic compounds which are currently in the limelight all over the world due to their beneficial effects on the human body. The potential of Vam3 as an antioxidant was determined through the evaluation of some key thermodynamic parameters which are commonly used for this purpose and describe the antioxidant activity quite well. Various mechanisms through which antioxidants usually can carry out their action were also explored both in water and in apolar environment. The results indicated that Vam3 is an excellent candidate as a natural antioxidant.
Highlights
Free radicals are reactive and unstable molecular entities that can form within our body when a closed-shell molecule, subjected to the stress of radiation and harmful agents, loses or gains an electron or undergoes a reaction such as hydrogen loss
The most common reaction mechanisms through which antioxidants exert their protection role and which we have examined can be divided roughly in two categories: one step (HAT and radical adduct formation (RAF)) and two steps processes (SPLET and single electron electron transfer—proton transfer (SET-PT)) [17,18,21]
We have found eight possible adducts formed mainly with the carbon atoms of the RAF mechanism ·OOH free radical can bind to the carbon atoms of Vam3 to form the so called radical rings C and D where there is a good conjugate system and that is the part shared by Vam3 with adducts
Summary
Free radicals are reactive and unstable molecular entities that can form within our body when a closed-shell molecule, subjected to the stress of radiation and harmful agents, loses or gains an electron or undergoes a reaction such as hydrogen loss. In the presence of an accumulation of free radicals we talk instead of oxidative stress. This will cause injury to a large number of biomolecules with the formation of compounds that can lead to severe dysfunction of the cells that in turn can contribute to the genesis and development of a large number of diseases [1,2,3,4]. The antioxidants that are taken from the outside to reinforce the cellular systems and defend them from free radicals include some vitamins, plant polyphenols and some trace elements essential for the functioning of the body0 s antioxidant enzymes (selenium, copper, manganese and zinc). Justify the continuous impetus to explore natural growing consumer preferences.
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