Abstract
Antioxidants are frequently used in several dietary supplements and have been probed for their significant role in the prevention of diseases like cancer or coronary heart disease. Acetyl salicylic acid has grabbed substantial attention due to their ability in impeding oxidative stress. In the present study, nine new salicylic acid derivatives: 5-(2-hydroxyphenyl-5-substituted)-1,3,4-oxadiazole-2(3H)-thiones, N-(2,5-dimethyl-1H-pyrrol-1-yl)-2-hydroxy-5-substituted benzamides, 2-hydroxy-5-substituted-N'-[1-(2-oxo-2substituted-chromen-3-yl)ethylidene] benzohydrazides and Hg (II) complex of N'-[(1Z)-1-(6-bromo-2-oxo-2H-chromen-3-yl) ethylidene]-2-hydroxybenzohydrazide have been synthesized and characterized in the light of advanced spectral techniques. The antioxidant properties of these compounds were investigated using 2,2-diphenyl-1-picrylhydrazyl (DPPH) spectrometric assay and compared with the results of cyclic voltammetry studies. The redox properties shown by the active molecule using cyclic voltammetry correlated well with the biochemical study.
Highlights
Reactive oxygen species (ROS) are extremely reactive molecules that contain oxygen like superoxides, hydroxyl radicals, peroxides etc. which are normally generated as a byproduct of the natural oxygen metabolism that occurs within cells (Muller, 2000; Schumacker, 2006)
The current study provides the synthesis of few salicylic acid derivatives and their mercury based complexes followed by the investigation of their antioxidant potential
The IR analysis showed that in this mononuclear mercury (II) complex, the Hg2+ ions are surrounded by one nitrogen and two oxygen atoms from the schiff base ligand and the two Cl atoms
Summary
Reactive oxygen species (ROS) are extremely reactive molecules that contain oxygen like superoxides, hydroxyl radicals, peroxides etc. which are normally generated as a byproduct of the natural oxygen metabolism that occurs within cells (Muller, 2000; Schumacker, 2006). Oxidative stress produced due to increased levels of either endogenous or exogenous ROS on exposure to ionic radiations or alterations in metabolic pathways can lead to severe consequences like ageing, DNA damage, lipid peroxidation, oxidation of amino acids in proteins, deactivation of certain enzymes eventually resulting in conditions like inflammation, cardiovascular disorders, neurodegenerative diseases or cancer (Renschler 2004; Li et al, 2013). Phenolic compounds like acetyl salicylic acid and its metabolite salicylic acid exhibit significant non-enzymatic antioxidant potential via donation of hydrogen atom from the hydroxyl moiety attached to the phenyl ring and prevent oxidative stress (Ghasemzadeh et al, 2012; BalDemirci et al, 2015). The potential prominence of antioxidants has encouraged us to investigate the cooperative effects of metal complexes and salicylic acid derivatives for improving antioxidant activity. The current study provides the synthesis of few salicylic acid derivatives and their mercury based complexes followed by the investigation of their antioxidant potential
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