Abstract
2 Abstract: The study was designed to investigate the antioxidant potential of Magnifera indica young leave methanolic extract in alloxan induced diabetic rat. Albino rats each weighing 100-200g were given a peritoneal injection of 120mg of Alloxan per kg body weight. After 7 days the blood glucose level of th e animals were checked to ascertain a diabetic state. Those that were diabetic were selected for the study. Significant increase (p<0.05) in lipid peroxidation and reduction in reduced glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT) was observed in the serum, liver, kidney and heart of diabetic rats as compared to the normal control. Administering Magnifera indica young leave extract significantly reduced (p<0.05) lipid peroxidation and elevated the level of GSH, SOD, and CAT in serum, liver, kidney and heart of diabetic rats compared to untreated diabetic rats. These findings indicate that Magnifera indica young leave extract can reduce free radical mediated oxidative stress to cells in experimental diabetes mellitus.
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