Abstract
This study aimed to evaluate the antioxidant activity of various plant extracts. A total of 94 kinds of edible plant extracts obtained from the Korea Plant Extract Bank were screened for cytotoxicity, following which the total phenolic content of 24 shortlisted extracts was determined. Of these, extracts from three plants, namely, Castanea crenata (CC) leaf, Camellia japonica (CJ) fruit, and Viburnum dilatatum (VD) leaf, were examined for antioxidant capabilities by measuring radical scavenging activity, ferric reducing/antioxidant power, and lipid peroxidation inhibitory activity. In addition, cellular antioxidant activities of the three extracts were assessed by a cell-based dichlorofluorescein assay and antioxidant response element (ARE) reporter activity assay. The results demonstrated that all three extracts concentration-dependently scavenged free radicals, inhibited lipid peroxidation, reduced the cellular level of reactive oxygen species, and increased ARE-luciferase activity, indicating antioxidant enzyme-inducing potential. In particular, CJ extract showed significantly greater antioxidative activity and antimigratory effect in a breast cancer cell line compared to CC and VD extracts. Hence, CJ extract deserves further study for its in vivo functionality or biologically active constituents.
Highlights
Oxidative stress caused by free radicals and their derivatives leads to disturbances in redox homeostasis [1]
A number of studies attribute health benefits of dietary plants to biologically active constituents that possess strong antioxidant activity [6]. This has resulted in extensive studies on plant extracts or constituents that are capable of scavenging free radicals and inhibiting lipid peroxidation [7, 8]
A total of 94 plant extracts were screened for cytotoxicity and a selection of them were tested for total phenolic content
Summary
Oxidative stress caused by free radicals and their derivatives leads to disturbances in redox homeostasis [1]. When intracellular oxidative status increases, the cell triggers its defense systems or undergoes apoptosis [2]. These responses to oxidative stress influence numerous cellular processes including core signaling pathways, which are associated with development of systematic and/or chronic disorders including aging and cancer [3, 4]. A number of studies attribute health benefits of dietary plants to biologically active constituents that possess strong antioxidant activity [6] This has resulted in extensive studies on plant extracts or constituents that are capable of scavenging free radicals and inhibiting lipid peroxidation [7, 8]
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