Antioxidant Potential of Artocarpusaltilis Leaf Powder in Alloxan Induced Diabetic Rat

Abstract

The possible protective effect of Artocarpus altilis leaf powder on diabetes‐induced oxidative stress was evaluated in alloxan‐induced diabetic male rat. Albino rats each weighing about 100 ± 25g were divided into five groups (A–E) (where n=8). Group A is the control fed with normal diet, Group D was pre‐treated with supplemented 5% A. altilis leaf powder for four weeks before induction with alloxan. Thereafter, groups B, C, D, and E were induced with 75mg/kg body weight of alloxan. However, group C was treated after induction with 5% A. altilis leaf powder supplemented diet and E with metformin. Significant increase (P<0.05) in lipid peroxidation and decrease in Superoxide dismutase (SOD), Catalase (CAT) and reduced glutathione (GSH), were observed in the diabetic control compared with the control rats. However, pretreatment with A. altilis leaf powder supplemented diet (Grp. D) and treatment of diabetic rats with same diet (Grp. C) resulted in a reduced lipid peroxidation and significant increase (P<0.05) in the activity of SOD, CAT, and GSH concentration in the serum, liver, and kidney of these group of rats compared with the diabetic control. These findings indicate that A. altilis leaf powder supplemented diet has a potential to reduce free radical mediated oxidative stress to cells in experimental diabetic rats. The pretreated A. altilis leaf powder supplemented diet was found to be more effective in restoring the values of these parameters to normal values, thus lending credence to its folkloric usage in the management and/or control of diabetes mellitus and possible use as a nutraceuticalSupport or Funding InformationnilThis abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.