Abstract
To explore new biocompatible antioxidants with the least associated side-effects, the present study was carried out to evaluate the antioxidant activity of leaf extracts of Abutilon indicum L. (Malvaceae). The methanol extract was prepared and screened for in vitro antioxidant activities using Ferric Reducing Antioxidant Power (FRAP) assay. The reducing power of a methanolic leaf extract of Abutilon indicum was markedly enhanced with the increasing concentrations. In addition, the potential antioxidant(s) from the plant extract of Abutilon indicum were partially purified by thin layer chromatography. The results indicate a strong antioxidant activity of the extract.
Highlights
The free radical mediated damage may play role in many disorders, in particular coronary heart disease (CHD), diabetes and cancer [1,2]
The use of traditional medicine is widespread in Africa and medicinal plants are still a large source of natural antioxidants that might serve as leads for the development of novel drug against free radical induced diseases
The assay was carried out in a total volume of 1.0 ml containing a suitable aliquot of plant extract (at concentration dependent (10-50 μg) and at volume dependent (10-100 μl) manner) in 0.1 ml and 900 μl of freshly prepared Ferric Reducing Antioxidant Power (FRAP) reagent, prepared by mixing 10.0 ml of 22.78 mM sodium acetate buffer, pH 3.6, 1.0 ml of 20 mM ferric chloride and 1.0 ml of 10 mM 2, 4, 6-tripyridyl-s-triazine solution prepared in 40 mM HCl
Summary
The free radical mediated damage may play role in many disorders, in particular coronary heart disease (CHD), diabetes and cancer [1,2]. [8] Plants contain several compounds such as phenolics, terpenoids, flavanoids, pigments and other natural oxidants including Vitamin A, Vitamin C and Vitamin E that have been associated with protection from treatment of chronic diseases such as heart diseases, cancer, diabetes and hypertension as well as other medicinal conditions [9]. It has been reported in the Siddha system of medicine as a remedy for jaundice, piles, ulcers & leprosy [10]. To explore new biocompatible antioxidants with the least associated side-effects, the present study was carried out to partially purify Abutilon indicum leaf extract and to evaluate the antioxidant activity of the extract
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