Abstract
The diversity of plants in Armenia is due to the singularity of natural environment. However, biochemical activity of these plants has not been studied well. The goal was to investigate biological activities as well as antihyperglycemic properties of Rumex obtusifolius L. in rabbits with hyperglycemia. According to obtained data, R. obtusifolius extracts possessed high antioxidant activity in chemical-based tests. GS/MS analysis of its methanol extracts allowed identification of several compounds, which could have high contribution on biological activities. The sub-cytotoxic concentration of investigated extract was 10 mgmL-1on Murine microglial BV-2 WT cell lines. Oral administration of ethanol extract showed significant effect on hyperglycemia, reducing fasting glucose levels (57.3%, p<0.05) and improving glucose tolerance. These findings suggest that R. obtusifolius extracts could be source of new biologically active compounds and recommended for treatment of diabetes mellitus.
Highlights
Armenia is positioned at the junction of several biogeographical zones and appears to be rich in health promoting edible or medicinal plants
R. obtusifolius or broad-leaved dock is well known herb which have been widely used in traditional medicine from ancient times for treatment of infectious diseases, skin rash, mucosal inflammations, etc.[14]
TLC-bioautographic analysis allowed separating active antimicrobial fractions from R. obtusifolius extracts against Staphylococcus aureus MDC 5233 and describing the chemical nature of those compounds [14]
Summary
Armenia is positioned at the junction of several biogeographical zones and appears to be rich in health promoting edible or medicinal plants. These zones are closely linked, resulting in relatively few endemic species of Armenian flora. Armenian flora is rich with with herb species which have been widely used in traditional medicine since ancient times [1]. This biodiversity was not studied properly for their biological activities, biochemical properties, including antioxidant properties [2], and hypoglycemic activities [3]. There could be hidden a great potential for their antioxidant properties and antihyperglycemic effects which can has huge value for therapeutic uses, as well as food industry [4]
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