Abstract
Mangiferin, a natural antioxidant additive, was incorporated into an ethylene vinyl acetate copolymer (EVA) containing 18% vinyl acetate (VA) using the emulsion solvent evaporation technique. Sorbitan ester (Span ® 20) and polymeric surfactant (Pluronic ® P−123) were compared. Mangiferin was finely dispersed in the suspension with the addition of surfactants studied. Span ® 20 was chosen as the surfactant for film preparation in the next step due to the dispersing and film forming properties. Effects of vinyl acetate (VA) contents on the film properties were investigated. The EVA films with 12% VA had the highest tensile strength and oxygen barrier, followed by 18, 25 and 40% VA, respectively. Addition of Span ® 20 had only a slight effect on mechanical and barrier properties of the films, but markedly increased the release of mangiferin from the EVA matrices except in the 40% VA films. The maximum concentrations of mangiferin released from the 40, 25, 18 and 12% VA films into 95% ethanol were 83.30, 66.84, 51.77 and 34.57 μg·mL −1 1, respectively. The release concentrations from the 40 and 25% VA films was 2.4 and 1.9 folds of that from the 12% VA film, respectively. The antioxidant activity of the EVA films containing mangiferin and Span ® 20 was 80% radical-scavenging capacity (RSC) for the 40 and 25% VA and 60% RSC for the 18 and 12% VA. The release of mangiferin from the EVA matrices may be controlled by appropriate selection of the surfactants and vinyl acetate contents.
Highlights
Mangiferin is a xanthone derivative, abundant in several parts of mango (Mangifera indica) such as leaves, peels and barks [1]
In the presence of surfactants, mangiferin particles were finely dispersed in the ethylene vinyl acetate copolymer (EVA) films
Span®20 was chosen to be used because it provided smaller droplet sizes and more stable microemulsion and the film with flexibility similar to the EVA film without surfactant
Summary
Mangiferin is a xanthone derivative, abundant in several parts of mango (Mangifera indica) such as leaves, peels and barks [1]. Several efforts have been made to increase the solubility and bioavailability of mangiferin, for example an encapsulation of mangiferin in cyclodextrin derivatives [3, 4] and microspheres of pectin calcium and chitosan [5]. Solid dispersion is applied for the improvement of the dissolution rate, and used for controlled release of active substances. This technique has widely been used for drug delivery system for several benefits. This study was aimed at applying this technique to incorporate mangiferin in EVA copolymer that can be used for antioxidant materials
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
